DHX36 and TLR1

Data Source:
HPRD (two hybrid)

		DHX36	TLR1
Description		DEAH-box helicase 36	toll like receptor 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Intracellular Anatomical Structure Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Perikaryon Extracellular Exosome	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Membrane Raft
	Molecular Function	Magnesium Ion Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding G-quadruplex RNA Binding DNA Helicase Activity Single-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA 3'-UTR Binding Protein Binding ATP Binding DNA-dependent ATPase Activity MRNA 3'-UTR AU-rich Region Binding Histone Deacetylase Binding MRNA 5'-UTR Binding G-quadruplex DNA Binding Telomerase RNA Binding Pre-miRNA Binding	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Ossification Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of Transcription By RNA Polymerase III Spermatogenesis RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Interferon-alpha Production Cellular Response To Heat Cellular Response To UV Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of MRNA Stability G-quadruplex DNA Unwinding Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Defense Response To Virus Positive Regulation Of Cardioblast Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Dendritic Spine Morphogenesis 3'-UTR-mediated MRNA Destabilization Telomerase RNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spermatogenesis Cellular Response To Arsenite Ion Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Intracellular MRNA Localization Positive Regulation Of Cytoplasmic Translation	Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Innate Immune Response Cellular Response To Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production	ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Body mass index ( 29273807) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Composite immunoglobulin trait (IgG/IgM) ( 28628107) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		71 interacting genes: DUX4 IL7R MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I TLR1 ZFP36	9 interacting genes: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1
Entrez ID		170506	7096
HPRD ID		09918	03119
Ensembl ID		ENSG00000174953	ENSG00000174125
Uniprot IDs		Q9H2U1	Q15399
PDB IDs		2N16 2N21 6Q6R	1FYV 2Z7X 6NIH
Enriched GO Terms of Interacting Partners?
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