GSDME and GARS1

Data Source:
BioGRID (proximity labelling technology)

		GSDME	GARS1
Description		gasdermin E	glycyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding	Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Protein Dimerization Activity
	Biological Process	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation
Pathways			Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs			Glycine
Diseases		Deafness, autosomal dominant	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS
Interacting Genes		3 interacting genes: ITGB1BP1 PTN TIFA	11 interacting genes: CD44 CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8
Entrez ID		1687	2617
HPRD ID		02996	02617
Ensembl ID		ENSG00000105928	ENSG00000106105
Uniprot IDs		A0A024RA58 A4FVA8 O60443	A0A090N8G0 A0A6Q8PGW4 P41250
PDB IDs			2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M
Enriched GO Terms of Interacting Partners?
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