DHX8 and THOC1

Data Source:
BioGRID (two hybrid)

		DHX8	THOC1
Description		DEAH-box helicase 8	THO complex 1
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GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Body U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing	Regulation Of DNA Recombination RNA Processing RNA Export From Nucleus MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA 3'-end Processing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: MFAP1 NKAP PRPF38A PRPF40A RBM7 RBMX2 SAP30BP SRPK1 SRPK2 THOC1 ZCCHC10	26 interacting genes: AGR2 AKAP9 BHLHB9 CTAG1A CTAG1B DHX8 EXOC5 FRA10AC1 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C RABGEF1 RB1 REL SAP30BP SF3B2 TADA2A TRIM27 TRIM54 USHBP1 WDR77 ZMYND12
Entrez ID		1659	9984
HPRD ID		02672	09498
Ensembl ID		ENSG00000067596	ENSG00000079134
Uniprot IDs		B7Z8F4 F5H658 Q05CV4 Q14562 Q86YB2	Q96FV9
PDB IDs		2EQS 3I4U 5MQF 5XJC 6HYS 6HYT 6HYU 6ICZ 6QDV	1WXP
Enriched GO Terms of Interacting Partners?
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