CCDC116 and CARD10

Data Source:
BioGRID (two hybrid)

		CCDC116	CARD10
Description		coiled-coil domain containing 116	caspase recruitment domain family member 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome	Cytoplasm CBM Complex
	Molecular Function	Protein Binding	Protein Binding Signaling Receptor Complex Adaptor Activity CARD Domain Binding
	Biological Process		Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process Protein-containing Complex Assembly Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Localization To Nucleus
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)	Autoimmune hepatitis type-1 ( 24768677) Low vWF levels ( 26486471) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc size ( 31809533) Refractive error ( 32231278) Vertical cup-disc ratio ( 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		32 interacting genes: AKAP9 BEX3 CARD10 CCDC85B CDCA7L CEP20 CEP44 COG6 CSNK2A1 CTAG1A CTAG1B FAM9B GOLGA6L9 HSF2BP IGFBP6 KRT31 KRT40 KRTAP4-12 MDFI MEIS3 MTUS2 NUTM1 PKNOX2 PPP1R16A RASSF10 SLC2A4 TADA2A TFIP11 TRAF1 USHBP1 ZMYND12 ZNF655	105 interacting genes: ATXN7 BAHD1 BCL10 BCL6B C4orf45 C8orf48 CARD9 CATSPER1 CBX8 CCDC116 CCDC187 CDC37 CEP95 CHIC2 CNNM3 CWF19L2 CXCL16 CYSRT1 DHX57 DOCK2 DUSP26 FAM47B FOXD4L3 GADD45GIP1 GAS8 GFAP GIPC1 GPATCH2L GSE1 GSTP1 HBZ HOXB9 IKBKG IL16 JOSD1 KANK2 KDM1A KEAP1 KLHL12 KRT75 KRTAP10-8 KRTAP12-3 KRTAP26-1 KRTAP9-2 KRTAP9-3 LENG1 MAGOHB METTL17 MITD1 MYPOP NME7 OLIG3 PIBF1 PKP1 PNKP PRDM14 PRPF18 PRPF3 PRR35 PTCD1 PTGDS RIN1 SCNM1 SEMA3B SPATA18 TBC1D22B TBC1D26 TFAP2D TMEM43 TRIM27 TRIM41 USP54 UTP14C ZBTB26 ZFP1 ZNF10 ZNF12 ZNF165 ZNF180 ZNF202 ZNF223 ZNF239 ZNF250 ZNF285 ZNF286A ZNF32 ZNF329 ZNF366 ZNF414 ZNF415 ZNF439 ZNF440 ZNF524 ZNF552 ZNF559 ZNF564 ZNF575 ZNF581 ZNF587 ZNF613 ZNF670 ZNF775 ZNF80 ZNF837 ZSCAN25
Entrez ID		164592	29775
HPRD ID		08203	06233
Ensembl ID		ENSG00000161180	ENSG00000100065
Uniprot IDs		Q8IYX3	Q9BWT7
PDB IDs
Enriched GO Terms of Interacting Partners?
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