DDB1 and TP73

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		DDB1	TP73
Description		damage specific DNA binding protein 1	tumor protein p73
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Chromatin Nucleus Nucleoplasm Mitochondrion Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Identical Protein Binding Metal Ion Binding MDM2/MDM4 Family Protein Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Viral Process Protein Ubiquitination Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination DNA Damage Response, Detection Of DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Biological Process Involved In Interaction With Symbiont Global Genome Nucleotide-excision Repair UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell	Activation Of MAPK Activity Kidney Development Mismatch Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Organonitrogen Compound Regulation Of Gene Expression Viral Process Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Hepatocellular carcinoma
GWAS			Joint damage in rheumatoid arthritis ( 31596875) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738) Waist-hip ratio ( 28552196)
Interacting Genes		44 interacting genes: ABL1 BRAP CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 GPS1 GSPT1 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MUS81 PIN1 PTEN RASSF1 SALL2 SIN3A SIRT7 SKP2 STAT1 SUPT3H SUV39H1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZNF277	63 interacting genes: ABL1 ATF3 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP CSNK2A1 DAXX DDB1 EP300 FBXO45 FLNA HCK HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MUL1 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PLK1 PML PPP1R13B PRKACB RACK1 RANBP9 RCHY1 RPL11 RPL5 SIRT1 SMAD2 SMAD3 SP1 SP3 SUMO1 TP53 TP63 TRIM28 UBE2D3 UBE2I WT1 WWOX XPO1 YAP1
Entrez ID		1642	7161
HPRD ID		10952	03587
Ensembl ID		ENSG00000167986	ENSG00000078900
Uniprot IDs		Q16531	A0A0C4DFW9 A1PQX5 O15350
PDB IDs		2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML	1COK 1DXS 2KBY 2MPS 2NB1 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ 5HOB 5HOC 5KBD 6FGS 6IJQ
Enriched GO Terms of Interacting Partners?
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