DCTN1 and ZNF512B

Data Source:
BioGRID (two hybrid)

		DCTN1	ZNF512B
Description		dynactin subunit 1	zinc finger protein 512B
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GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage	Nucleoplasm
	Molecular Function	Motor Activity Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding Microtubule Plus-end Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Nuclear Migration Nervous System Development Neuromuscular Junction Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Envelope Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Perry syndrome Distal hereditary motor neuropathies (dHMN)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)	Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732)
Interacting Genes		46 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 ENO3 FBXL5 GRB2 GSK3B HAP1 HSPB2 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B	71 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX
Entrez ID		1639	57473
HPRD ID		07206	13840
Ensembl ID		ENSG00000204843	ENSG00000196700
Uniprot IDs		Q14203 Q6MZZ3	Q96KM6
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7	2GQJ
Enriched GO Terms of Interacting Partners?
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