STOML3 and ADCY3

Data Source:
HPRD (in vivo)

		STOML3	ADCY3
Description		stomatin like 3	adenylate cyclase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Plasma Membrane Cilium Integral Component Of Membrane Membrane Raft	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Protein Binding	Adenylate Cyclase Activity Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	Signal Transduction Biological_process Ion Transmembrane Transport	Renal Water Homeostasis CAMP Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Single Fertilization Acrosome Reaction Sensory Perception Of Smell Olfactory Learning Flagellated Sperm Motility Activation Of Protein Kinase A Activity Cellular Response To Glucagon Stimulus Cellular Response To Forskolin
Pathways		Stimuli-sensing channels	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Metabolic syndrome ( 20694148)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 2 years old ( 31575865) BMI at 3 years old ( 31575865) BMI at 5 years old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 28552196 22344219 29381148 26426971 26961502 24861553 31453325 28892062 25673413 20935630 29273807 23583978 28448500 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in non-asthmatics ( 23517042) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 29059683) Childhood body mass index ( 33045005 26604143) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronotype ( 30696823) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Dentures ( 31235808) Diastolic blood pressure ( 28135244 27841878 30578418) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340 18391951) Height adjusted BMI ( 25044758) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 30677029) Pubertal anthropometrics ( 23449627) Reticulocyte count ( 32888494 27863252) Systolic blood pressure ( 27841878 30578418) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299)
Interacting Genes		9 interacting genes: ADAM33 ADCY3 APP CAV1 CLDN19 JAGN1 SEC22A UPK2 ZDHHC24	3 interacting genes: CAMK2G MTNR1B STOML3
Entrez ID		161003	109
HPRD ID		16315	02620
Ensembl ID		ENSG00000133115	ENSG00000138031
Uniprot IDs		Q8TAV4	A0A0A0MSC1 B7ZLX9 O60266
PDB IDs
Enriched GO Terms of Interacting Partners?
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