TAMALIN and DOCK1

Data Source:
BioGRID (pull down, fluorescent resonance energy transfer, affinity chromatography technology)

		TAMALIN	DOCK1
Description		trafficking regulator and scaffold protein tamalin	dedicator of cytokinesis 1
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GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Postsynaptic Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	PDZ Domain Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Signal Transduction Protein Localization Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane	Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Positive Regulation Of Epithelial Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		11 interacting genes: CYTH3 DLG4 DOCK1 FYN GABBR2 GRM1 GRM2 GRM3 GRM5 RPS6KA1 SRC	11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2
Entrez ID		160622	1793
HPRD ID		17077	03240
Ensembl ID		ENSG00000161835	ENSG00000150760
Uniprot IDs		Q7Z6J2	A0A2X0U2H5 B2RUU3 Q14185
PDB IDs		2PNT	3L4C
Enriched GO Terms of Interacting Partners?
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