AP2A1 and CLINT1

Data Source:
HPRD (in vitro)

		AP2A1	CLINT1
Description		adaptor related protein complex 2 subunit alpha 1	clathrin interactor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Endolysosome Membrane Clathrin-coated Endocytic Vesicle	Nucleoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding Cargo Adaptor Activity	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Neuron Projection Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Ephrin Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Endocytosis Clathrin Coat Assembly
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Diastolic blood pressure ( 27841878) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		28 interacting genes: AAGAB AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC	14 interacting genes: AP1G1 AP2A1 AP2B1 CALM1 CLTC DNM1 EPS15 GDPD5 GGA1 GGA2 GGA3 JUN VTI1B YWHAG
Entrez ID		160	9685
HPRD ID		03016	06273
Ensembl ID		ENSG00000196961	ENSG00000113282
Uniprot IDs		O95782	A0A0S2Z4Y4 A0A0S2Z5H3 Q14677
PDB IDs			1XGW 2QY7 2V8S
Enriched GO Terms of Interacting Partners?
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