CYP11A1 and CYP11B2

Data Source:
HPRD (in vitro)

		CYP11A1	CYP11B2
Description		cytochrome P450 family 11 subfamily A member 1	cytochrome P450 family 11 subfamily B member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Heme Binding	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Corticosterone 18-monooxygenase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Drugs		Aminoglutethimide	Spironolactone Osilodrostat
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)	Glucocorticoid-remediable aldosteronism (GRA) Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency
GWAS		Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)	Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)
Interacting Genes		5 interacting genes: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9	3 interacting genes: CYP11A1 CYP11B1 FDX1
Entrez ID		1583	1585
HPRD ID		00326	00492
Ensembl ID		ENSG00000140459	ENSG00000179142
Uniprot IDs		A0A0S2Z3R3 P05108	P19099
PDB IDs		3N9Y 3N9Z 3NA0 3NA1	4DVQ 4FDH 4ZGX 6XZ8 6XZ9
Enriched GO Terms of Interacting Partners?
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