CYP2C8 and BLMH

Data Source:
BioGRID (two hybrid)

		CYP2C8	BLMH
Description		cytochrome P450 family 2 subfamily C member 8	bleomycin hydrolase
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding
	Biological Process	Lipid Hydroxylation Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Retinol Metabolic Process Retinoic Acid Metabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Protein Polyubiquitination Proteolysis Response To Toxic Substance Response To Drug Homocysteine Catabolic Process
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS		Blood metabolite levels ( 24816252) Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)
Interacting Genes		12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32	20 interacting genes: AP1M2 APP CDC42 CYP2C8 ECSIT KBTBD7 MAST1 NTAQ1 NUDT12 NXF1 PDPK1 PGLS RNF32 RPL11 RPL29 TNPO2 TNPO3 TRIM47 TRIO UBE2I
Entrez ID		1558	642
HPRD ID		03083	03870
Ensembl ID		ENSG00000138115	ENSG00000108578
Uniprot IDs		B7Z1F5 P10632	Q13867
PDB IDs		1PQ2 2NNH 2NNI 2NNJ 2VN0	1CB5 2CB5
Enriched GO Terms of Interacting Partners?
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