PLB1 and S100A1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PLB1	S100A1
Description		phospholipase B1	S100 calcium binding protein A1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Sarcoplasmic Reticulum Protein-containing Complex
	Molecular Function	Phospholipase Activity Lysophospholipase Activity Phospholipase A2 Activity Triglyceride Lipase Activity Retinyl-palmitate Esterase Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Retinoid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Retinol Metabolic Process Positive Regulation Of Acrosome Reaction	Toll-like Receptor Signaling Pathway Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sprouting Angiogenesis
Pathways		Acyl chain remodelling of PC Retinoid metabolism and transport	Regulation of TLR by endogenous ligand
Drugs			Olopatadine
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549) Intracranial aneurysm ( 29531279) Neutrophil percentage of granulocytes ( 27863252) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Sum eosinophil basophil counts ( 27863252) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		8 interacting genes: FRS3 HSF2BP NLGN3 PIK3R3 RIN3 S100A1 TNS2 TSEN15	30 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1
Entrez ID		151056	6271
HPRD ID		15141	01489
Ensembl ID		ENSG00000163803	ENSG00000160678
Uniprot IDs		B2RWP8 Q6P1J6	A0A0S2Z4H2 P23297
PDB IDs			2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89
Enriched GO Terms of Interacting Partners?
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