CTSE and EDN3

Data Source:
HPRD (in vitro)

		CTSE	EDN3
Description		cathepsin E	endothelin 3
Image
GO Annotations	Cellular Component	Endosome	Extracellular Region Extracellular Space
	Molecular Function	Aspartic-type Endopeptidase Activity Peptidase Activity Identical Protein Binding	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding
	Biological Process	Proteolysis Protein Autoprocessing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		MHC class II antigen presentation	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases			Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS) Waardenburg syndrome (WS)
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hypertension ( 19430479 21909115) Metabolite levels ( 23823483) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		5 interacting genes: A2M BAG6 EDN3 EMG1 INS	5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		1510	1908
HPRD ID		00294	00570
Ensembl ID		ENSG00000196188	ENSG00000124205
Uniprot IDs		B4DNU8 P14091	P14138 Q4FAT2
PDB IDs		1LCG 1TZS	6IGK
Enriched GO Terms of Interacting Partners?
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