CTSB and SLPI

Data Source:
HPRD (in vitro)

		CTSB	SLPI
Description		cathepsin B	secretory leukocyte peptidase inhibitor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Anatomical Structure Lysosome Apical Plasma Membrane Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Toll-like Receptor Signaling Pathway Proteolysis Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Neutrophil Degranulation Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modulation Of Process Of Other Organism Neutrophil Degranulation Negative Regulation Of Viral Genome Replication Innate Immune Response
Pathways		Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation	Neutrophil degranulation
Drugs		2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases		Tropical calcific pancreatitis
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 29875488 28240269) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 32201043 28892059) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)
Interacting Genes		37 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1	25 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2
Entrez ID		1508	6590
HPRD ID		00287	00121
Ensembl ID		ENSG00000164733	ENSG00000124107
Uniprot IDs		A0A024R374 B4DMY4 P07858 Q5HYG5	P03973
PDB IDs		1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2	2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?
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