HSCB and BBS2

Data Source:
BioGRID (two hybrid)

		HSCB	BBS2
Description		HscB mitochondrial iron-sulfur cluster cochaperone	Bardet-Biedl syndrome 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytosol Microvillus Membrane Motile Cilium Stereocilium BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane
	Molecular Function	ATPase Activator Activity Molecular_function Protein Binding Identical Protein Binding Metal Ion Binding Chaperone Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding
	Biological Process	Iron-sulfur Cluster Assembly Positive Regulation Of ATPase Activity [2Fe-2S] Cluster Assembly Protein Complex Oligomerization Protein Maturation By Iron-sulfur Cluster Transfer	Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Breast size ( 27182965) Diastolic blood pressure ( 27841878) Esophageal cancer and gastric cancer ( 20729852) Mean platelet volume ( 32888494) Myeloproliferative neoplasms ( 33057200) Pancreatic cancer ( 25086665) Red cell distribution width ( 27863252) Systolic blood pressure ( 27841878)
Interacting Genes		4 interacting genes: AGTRAP BBS1 BBS2 BBS4	15 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PSME3 RBPMS
Entrez ID		150274	583
HPRD ID		16289	05855
Ensembl ID		ENSG00000100209	ENSG00000125124
Uniprot IDs		A0A384NYJ4 B0QYH2 Q8IWL3	Q9BXC9
PDB IDs		3BVO
Enriched GO Terms of Interacting Partners?
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