SPC24 and SPC25

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SPC24	SPC25
Description		SPC24 component of NDC80 kinetochore complex	SPC25 component of NDC80 kinetochore complex
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Cycle Cell Division	Mitotic Spindle Organization Chromosome Segregation Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Circulating leptin levels or HOMA-B ( 32341051) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Fasting blood glucose ( 29621232) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN	4 interacting genes: HGS NDC80 SEC61B SPC24
Entrez ID		147841	57405
HPRD ID		15464	15465
Ensembl ID		ENSG00000161888	ENSG00000152253
Uniprot IDs		B4E086 Q8NBT2	Q9HBM1
PDB IDs		2VE7 3IZ0	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?