TOM1L2 and MYO6

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, two hybrid)

		TOM1L2	MYO6
Description		target of myb1 like 2 membrane trafficking protein	myosin VI
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Membrane Extracellular Exosome	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Clathrin Binding	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	Intracellular Protein Transport Signal Transduction Negative Regulation Of Mitotic Nuclear Division	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion
Pathways			Gap junction degradation Trafficking of AMPA receptors
Drugs
Diseases			Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Total body bone mineral density ( 29304378)	Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		11 interacting genes: APP FAM9B LAPTM5 MAP3K1 MYO6 NEDD4 RNF11 SMURF1 TOLLIP UBC WBP2	20 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2
Entrez ID		146691	4646
HPRD ID		18213	02985
Ensembl ID		ENSG00000175662	ENSG00000196586
Uniprot IDs		B7Z2U2 B7Z671 F5H3S6 Q6ZVM7	Q9UM54
PDB IDs			2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56
Enriched GO Terms of Interacting Partners?
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