CSF2RA and CSF2RB

Data Source:
HPRD (in vivo, in vitro)

		CSF2RA	CSF2RB
Description		colony stimulating factor 2 receptor subunit alpha	colony stimulating factor 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity	Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process	MAPK Cascade Signal Transduction Respiratory Gaseous Exchange By Respiratory System Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Cellular Protein Metabolic Process
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling
Drugs		Sargramostim KB002 Regramostim Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Clove oil	Sargramostim NPI 32101 Resatorvid
Diseases
GWAS		Schizophrenia ( 17522711)	Blood protein levels ( 30072576 29875488) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		9 interacting genes: CHUK CSF2 CSF2RB FATE1 IKBKB KIT LYN PIK3R1 RPSA	27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		1438	1439
HPRD ID		02381	00739
Ensembl ID		ENSG00000198223	ENSG00000100368
Uniprot IDs		P15509	P32927 Q6NSJ8
PDB IDs		4NKQ 4RS1	1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU
Enriched GO Terms of Interacting Partners?
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