CSF2 and SEMA7A

Data Source:
BioGRID (affinity chromatography technology)

		CSF2	SEMA7A
Description		colony stimulating factor 2	semaphorin 7A (John Milton Hagen blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Integrin Binding Protein Binding Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	MAPK Cascade Histamine Secretion Embryonic Placenta Development Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Myeloid Cell Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Osteoblast Differentiation Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Axon Guidance Olfactory Lobe Development Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Axon Extension Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	Other semaphorin interactions Other semaphorin interactions
Drugs		KB002
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Rheumatoid arthritis ( 30423114 22446963 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)
Interacting Genes		7 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 SDC2	1 interacting genes: PLXNC1
Entrez ID		1437	8482
HPRD ID		00734	07081
Ensembl ID		ENSG00000164400	ENSG00000138623
Uniprot IDs		P04141	B3KMH6 F5GYX3 O75326
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS	3NVQ
Enriched GO Terms of Interacting Partners?
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