CSF2 and SDC2

Data Source:
HPRD (in vivo)

		CSF2	SDC2
Description		colony stimulating factor 2	syndecan 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	MAPK Cascade Histamine Secretion Embryonic Placenta Development Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Myeloid Cell Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Biological_process Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis Leukocyte Migration
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport
Drugs		KB002	Sargramostim
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Rheumatoid arthritis ( 30423114 22446963 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 SDC2	28 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		1437	6383
HPRD ID		00734	00803
Ensembl ID		ENSG00000164400	ENSG00000169439
Uniprot IDs		P04141	A0A024R9D1 E9PBI9 P34741
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS	6ITH
Enriched GO Terms of Interacting Partners?
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