CSF2 and TREML2

Data Source:
BioGRID (biochemical)

		CSF2	TREML2
Description		colony stimulating factor 2	triggering receptor expressed on myeloid cells like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Histamine Secretion Embryonic Placenta Development Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Myeloid Cell Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	T Cell Activation Regulation Of Immune Response
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		KB002
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Rheumatoid arthritis ( 30423114 22446963 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Alzheimer's disease (late onset) ( 24162737) Blood protein levels ( 30072576 29875488) Monocyte count ( 27863252) Reticulocyte count ( 32888494) Type 2 diabetes ( 31049640) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 SDC2
Entrez ID		1437	79865
HPRD ID		00734	11646
Ensembl ID		ENSG00000164400	ENSG00000112195
Uniprot IDs		P04141	Q5T2D2
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?
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