CSF2 and FBN2

Data Source:
BioGRID (biochemical)

		CSF2	FBN2
Description		colony stimulating factor 2	fibrillin 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	MAPK Cascade Histamine Secretion Embryonic Placenta Development Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Myeloid Cell Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Anatomical Structure Morphogenesis Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		KB002	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Rheumatoid arthritis ( 30423114 22446963 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Brain morphology (MOSTest) ( 32665545) Breastfeeding duration ( 25475840) Central corneal thickness ( 32528159) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960)
Interacting Genes		7 interacting genes: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 SDC2	7 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2
Entrez ID		1437	2201
HPRD ID		00734	00416
Ensembl ID		ENSG00000164400	ENSG00000138829
Uniprot IDs		P04141	P35556
PDB IDs		1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?
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