CSF1 and SLA2

Data Source:
BioGRID (pull down)

		CSF1	SLA2
Description		colony stimulating factor 1	Src like adaptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex	Nucleoplasm Cytoplasm Late Endosome Golgi Apparatus Plasma Membrane Phosphatidylinositol 3-kinase Complex Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity	Protein Binding Signaling Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity Protein N-terminus Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Cytokine-mediated Signaling Pathway Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration	Negative Regulation Of Transcription By RNA Polymerase II B Cell Mediated Immunity T Cell Activation Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation	Negative regulation of FLT3
Drugs
Diseases
GWAS		Adult onset Still's disease ( 32149159) Aspartate aminotransferase levels ( 29403010) Blood protein levels in cardiovascular risk ( 28369058) Creatine kinase levels ( 29403010) Height ( 31562340) Lactate dehydrogenase levels ( 29403010) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Serum total protein level ( 29403010) Total body bone mineral density ( 29304378) White blood cell count ( 32888494 27863252)
Interacting Genes		13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF	14 interacting genes: CBL CD247 CSF1 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LAMC2 MET PRKAA2 UBASH3A ZAP70
Entrez ID		1435	84174
HPRD ID		00388	05955
Ensembl ID		ENSG00000184371	ENSG00000101082
Uniprot IDs		A0A024R0A1 P09603	Q9H6Q3
PDB IDs		1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF	4M4Z
Enriched GO Terms of Interacting Partners?
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