DYDC1 and PPP2R5D

Data Source:
BioGRID (two hybrid)

		DYDC1	PPP2R5D
Description		DPY30 domain containing 1	protein phosphatase 2 regulatory subunit B'delta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region MLL3/4 Complex Set1C/COMPASS Complex	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Chromatin Silencing At Telomere Histone H3-K4 Methylation	Protein Dephosphorylation Signal Transduction Nervous System Development Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31451708)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		33 interacting genes: ARNT2 CCHCR1 CCNC CEP57L1 DPY30 ENKD1 HDAC4 HGS KRT75 LMO2 LNX1 MID2 MOS NME5 PDZD4 PIK3R2 PKN1 POU6F2 PPP2R5D PSMA1 TCHP TEAD4 TFPT TLE5 TSGA10IP TXLNB TXNDC9 USHBP1 USP2 VPS37C VPS9D1 WAC ZGPAT	18 interacting genes: CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DYDC1 FSD2 HAND1 HAND2 PPFIA1 PPP2R1A PPP2R1B PPP4C RORC SGO1 USHBP1
Entrez ID		143241	5528
HPRD ID		14062	09039
Ensembl ID		ENSG00000170788	ENSG00000112640
Uniprot IDs		Q8WWB3	A0A024RD11 Q14738
PDB IDs
Enriched GO Terms of Interacting Partners?
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