VTI1A and TMBIM6

Data Source:
BioGRID (two hybrid)

		VTI1A	TMBIM6
Description		vesicle transport through interaction with t-SNAREs 1A	transmembrane BAX inhibitor motif containing 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Autophagosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Clathrin-coated Vesicle SNARE Complex Late Endosome Membrane Trans-Golgi Network Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Neuron Projection Terminus Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity
	Biological Process	Protein Targeting To Vacuole Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Autophagy Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Voluntary Musculoskeletal Movement Golgi Ribbon Formation	Negative Regulation Of Immunoglobulin Production Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Negative Regulation Of Apoptotic Process Negative Regulation Of Endoribonuclease Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness ( 30510157) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 26965516 30529582 25105248) Colorectal cancer or advanced adenoma ( 30510241) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Evening vs. morning chronotype (sMEQ score) ( 32579418) Heel bone mineral density ( 30598549) Lung cancer ( 23143601) Multiple sclerosis ( 23412934) Non-glioblastoma glioma ( 28346443 26424050) Non-small cell lung cancer ( 31326317) QRS duration ( 30679814 27577874 31251759 27659466) Refractive error ( 32231278)	General cognitive ability ( 29844566)
Interacting Genes		2 interacting genes: STX16 TMBIM6	68 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MFSD14B MMGT1 MS4A3 ODF4 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 RNF185 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A
Entrez ID		143187	7009
HPRD ID		18290	02851
Ensembl ID		ENSG00000151532	ENSG00000139644
Uniprot IDs		Q96AJ9	A0A024R0Z5 P55061
PDB IDs
Enriched GO Terms of Interacting Partners?
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