CRX and MLLT6

Data Source:
BioGRID (two hybrid)

		CRX	MLLT6
Description		cone-rod homeobox	MLLT6, PHD finger containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Stimulus	Regulation Of Transcription, DNA-templated Positive Regulation Of Sodium Ion Transport Negative Regulation Of Urine Volume Renal Sodium Excretion Renal Potassium Excretion Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Histone H3-K79 Methylation
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS
Interacting Genes		112 interacting genes: AASDHPPT ABI2 ACBD4 ARIH2 ATG12 ATM ATP6V0D2 ATXN1 ATXN7 BANF1 BANF2 BANP BOD1L2 C19orf25 C1orf109 C1orf50 C1orf56 C9orf72 CA8 CCNC CDKN2C CFAP206 CREBBP CSNK1G2-AS1 CTNNA3 DELE1 EIF5A EP300 FAAP20 FOXH1 GCM2 GLIS2 GUCD1 GYS1 HGS HNF1B IGFN1 IPO13 IRX6 KANK2 KAT2A KLHL32 LARP4 LGALS3 LIMS3 LIMS4 LNX1 LONRF1 M1AP MDFI MLLT6 MYO15B MYOZ1 NEIL2 NFYC NIP7 NPAS2 NR2E3 NRL NTF4 OR6B1 OSGIN1 OSTF1 PDC PICALM PID1 PNMA6A POGZ PPP1R16B PRKAB2 PRKN PRR35 PSMA1 PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS RHOXF2 ROR2 SAE1 SDCBP SEC14L4 SFI1 SMAD3 SMAP1 SMAP2 SMUG1 SOX10 SOX14 SOX3 SOX5 SPG21 STK16 SUFU SUOX SZT2 TBX6 TCF7L2 TEX33 TFG TLE5 TLX3 TNS2 UBXN2B UBXN7 VPS37C ZC3H10 ZIC1 ZNF483 ZNF688	25 interacting genes: APP CASK CEBPE CEBPG CEP44 CREB5 CRX ENOX2 GRIPAP1 IKBKG KRTAP10-8 MED15 MEOX2 NSD3 PHC2 PIN1 SPRY2 TCF12 TCF4 TLE5 UBE2G2 UBQLN1 UBQLN4 ZBTB22 ZMYND19
Entrez ID		1406	4302
HPRD ID		03748	08978
Ensembl ID		ENSG00000105392	ENSG00000275023
Uniprot IDs		O43186	P55198
PDB IDs
Enriched GO Terms of Interacting Partners?
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