CREB1 and AGR2

Data Source:
BioGRID (two hybrid)

		CREB1	AGR2
Description		cAMP responsive element binding protein 1	anterior gradient 2, protein disulphide isomerase family member
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrial Matrix Axon ATF4-CREB1 Transcription Factor Complex	Extracellular Space Endoplasmic Reticulum
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Hsp70 Protein Binding Histone Acetyltransferase Binding CAMP Response Element Binding Identical Protein Binding Arrestin Family Protein Binding Sequence-specific Double-stranded DNA Binding	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Axonogenesis Aging Lactation Memory Circadian Rhythm Regulation Of Cell Size Visual Learning Response To Organic Substance Negative Regulation Of Transcription By Competitive Promoter Binding Response To Activity Viral Process Pituitary Gland Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Response To Glucagon Chemotaxis To Arachidonic Acid Response To Nicotine Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Response To Drug Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fibroblast Proliferation Protein Stabilization Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Glial Cell Proliferation Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion Cellular Response To Retinoic Acid Cellular Response To Fatty Acid Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neuron Death Response To L-glutamate Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways		PKA-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB AKT phosphorylates targets in the nucleus CREB phosphorylation Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis NOTCH2 intracellular domain regulates transcription NCAM signaling for neurite out-growth Circadian Clock Circadian Clock CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Constitutive Signaling by AKT1 E17K in Cancer Gastrin-CREB signalling pathway via PKC and MAPK Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands MECP2 regulates transcription factors NGF-stimulated transcription NGF-stimulated transcription HCMV Early Events Transcriptional regulation of granulopoiesis Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis
Drugs		Adenosine phosphate Naloxone
Diseases
GWAS		Body mass index ( 28892062 25673413) Diastolic blood pressure ( 27841878) Food antigen IgG levels ( 24962563) Mean corpuscular hemoglobin ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 27841878)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		80 interacting genes: ABL1 AGR2 AKT1 ATF1 ATF6 ATF7IP ATM ATR CAMK2A CCDC6 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 CRTC2 DNMT3L DYRK1A EDF1 ERG28 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HIVEP1 HNF1B HPS6 KAT5 KCNIP3 KIAA2026 MAPK14 MAPKAPK2 MTF2 NR3C1 PDX1 PIAS1 PIAS2 POGZ POU2F1 PPP1CA PRKACA PRKG1 RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RNF4 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SMCO1 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1
Entrez ID		1385	10551
HPRD ID		00442	05896
Ensembl ID		ENSG00000118260	ENSG00000106541
Uniprot IDs		B7Z5C6 P16220 Q53X93 Q5U0J5	O95994 Q4JM46
PDB IDs		2LXT 5ZK1 5ZKO	2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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