RNF183 and FBP1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RNF183	FBP1
Description		ring finger protein 183	fructose-bisphosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane Cis-Golgi Network Membrane	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Factor Binding Protein Binding AMP Binding Fructose 1,6-bisphosphate 1-phosphatase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process Response To Endoplasmic Reticulum Stress Protein Autoubiquitination Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Sucrose Biosynthetic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Dephosphorylation Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Cellular Response To Drug Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion
Pathways			Gluconeogenesis
Drugs			Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases			Fructose-1,6-bisphosphatase deficiency
GWAS			Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Colorectal or endometrial cancer ( 26621817) Obesity-related traits ( 23251661)
Interacting Genes		12 interacting genes: APP BCL2 BCL2L1 EWSR1 FATE1 FBP1 GOPC IFFO1 KXD1 TAX1BP3 UBE2K UBE2W	38 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DYNC1I1 ERBB2 FBP2 FBXW7 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 PCNX4 POT1 PRKN PTK2 PTPRJ RB1 RNF183 STK11 TERF1 TLR2 TRIM28
Entrez ID		138065	2203
HPRD ID		10082	01973
Ensembl ID		ENSG00000165188	ENSG00000165140
Uniprot IDs		A0A024R834 Q96D59	P09467 Q2TU34
PDB IDs			1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7CVN
Enriched GO Terms of Interacting Partners?
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