CPT1A and CYBA

Data Source:
BioGRID (two hybrid)

		CPT1A	CYBA
Description		carnitine palmitoyltransferase 1A	cytochrome b-245 alpha chain
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane Integral Component Of Mitochondrial Outer Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Secretory Granule Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Tertiary Granule Membrane
	Molecular Function	Carnitine O-palmitoyltransferase Activity Identical Protein Binding Palmitoleoyltransferase Activity	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Regulation Of Lipid Storage Response To Organic Cyclic Compound Regulation Of Lipid Metabolic Process Epithelial Cell Differentiation Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Response To Alkaloid Response To Ethanol Response To Antibiotic Regulation Of Insulin Secretion Cellular Response To Fatty Acid Liver Regeneration Response To Tetrachloromethane	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Inflammatory Response Smooth Muscle Hypertrophy Cytochrome Complex Assembly Electron Transport Chain Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		RORA activates gene expression PPARA activates gene expression Carnitine metabolism Signaling by Retinoic Acid	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping
Drugs		Levocarnitine Glyburide Perhexiline	Dextromethorphan
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) HDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 22286219) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Obesity-related traits ( 23251661) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549 32154731) Urate levels ( 31578528)	Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)
Interacting Genes		8 interacting genes: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1 UBC	13 interacting genes: APPBP2 CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2
Entrez ID		1374	1535
HPRD ID		02755	01989
Ensembl ID		ENSG00000110090	ENSG00000051523
Uniprot IDs		A0A024R5F4 B2RAQ8 P50416 Q8WZ48	B4DT46 H3BNP7 P13498
PDB IDs		2LE3	1WLP
Enriched GO Terms of Interacting Partners?
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