CLDN7 and IGFBP5

Data Source:
BioGRID (two hybrid)

		CLDN7	IGFBP5
Description		claudin 7	insulin like growth factor binding protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Structural Molecule Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Cell Adhesion Molecule Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Positive Regulation Of Cell Population Proliferation Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Apoptotic Process Response To Ethanol Bicellular Tight Junction Assembly Positive Regulation Of Cell Motility	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Tight junction interactions	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Birth weight ( 31043758 27680694) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758)	Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Visceral fat ( 22589738)
Interacting Genes		77 interacting genes: AIG1 ANKRD46 APOD AQP2 ASGR1 BCL2L2 BET1 BMP10 C3orf52 CD53 CD72 CLN6 CMTM5 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB561D2 CYB5B CYBC1 EDDM3B EMP3 EPCAM ERG28 ERMP1 FAXDC2 FXYD6 GIMAP5 GLP1R GPR37L1 HGD IGFBP5 ITM2A JAGN1 LAT LEPROTL1 LPAR3 LSMEM2 MAL MALL MFSD5 MS4A13 NDUFB11 NIPAL4 NKG7 OLFM4 PGAP2 PLN RHOXF2 RPRM RTP2 SCAMP4 SCARF1 SEC22B SERTM1 SLC38A7 SYNE4 TJP1 TMEM100 TMEM11 TMEM128 TMEM140 TMEM147 TMEM44 TMEM60 TMEM97 TNF TRARG1 TSPAN33 UBIAD1 UNC93B1 UPK1B UPK2 VAMP3 VAMP5 VSTM1	92 interacting genes: ABHD4 ADAM12 AHNAK2 AMIGO1 ANKS6 APH1A AQP2 AQP6 AQP9 ASGR1 BAG6 BSND CD53 CERS4 CHODL CLDN2 CLDN20 CLDN6 CLDN7 CLDN9 CLEC17A CREB3 CXCR1 ELOVL5 ERGIC3 F2 FAM209A FCRL3 FHL1 FHL2 FN1 FNDC9 GJA5 GJA8 GJB3 GJB5 GOLM1 GPR151 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HSD17B13 IGF1 IGF2 IGFALS KCNK5 KIAA2013 KPNB1 LAPTM4B LAYN LDLRAD1 LHFPL1 LMNA LTBP1 MFF MFSD5 MRPS18B MS4A3 MS4A7 NCAPH2 PAPPA2 PDZK1IP1 PNO1 PROKR2 RASSF1 RHCG SERPINE1 SLC10A6 SLC13A4 SLC38A1 SLC41A2 SLC41A3 SPAG4 SPP1 SYNE4 TF THAP4 THBS1 TLCD4 TMEM106A TMEM106C TMEM179B TMEM237 TMEM45A TMEM52B TMPRSS2 TMX2 TSPAN12 TSPO2 VTN
Entrez ID		1366	3488
HPRD ID		07633	00901
Ensembl ID		ENSG00000181885	ENSG00000115461
Uniprot IDs		A0A384ME58 F5H496 O95471	P24593
PDB IDs			1BOE 1H59
Enriched GO Terms of Interacting Partners?
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