CLDN4 and TRIM59

Data Source:
BioGRID (two hybrid)

		CLDN4	TRIM59
Description		claudin 4	tripartite motif containing 59
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Adhesion Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Establishment Of Skin Barrier Renal Absorption Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Chloride Transmembrane Transport Positive Regulation Of Metallopeptidase Activity	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response
Pathways		Tight junction interactions
Drugs
Diseases
GWAS			Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		19 interacting genes: AQP6 ARL13B CLEC14A EPHA2 FAM209A FFAR2 GJA8 GOLM1 HSD17B13 ICAM3 MFSD14B SHBG SYT2 TJP1 TMEM237 TMEM52B TRIM59 TSPO2 WNK4	26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		1364	286827
HPRD ID		04218	15568
Ensembl ID		ENSG00000189143	ENSG00000213186
Uniprot IDs		O14493 Q75L80	Q8IWR1
PDB IDs		5B2G
Enriched GO Terms of Interacting Partners?
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