STARD4 and SYP

Data Source:
BioGRID (two hybrid)

		STARD4	SYP
Description		StAR related lipid transfer domain containing 4	synaptophysin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Vesicle	Synaptic Vesicle Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Perinuclear Region Of Cytoplasm Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Binding Cholesterol Binding Cholesterol Transfer Activity	Protein Binding Cholesterol Binding Syntaxin-1 Binding SH2 Domain Binding Identical Protein Binding Protein Self-association
	Biological Process	Positive Regulation Of Cholesterol Esterification Cholesterol Transport Involved In Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Import Positive Regulation Of Bile Acid Biosynthetic Process Intermembrane Lipid Transfer	Endocytosis Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Membrane Organization Cellular Response To Organic Substance Regulation Of Synaptic Vesicle Exocytosis Regulation Of Opioid Receptor Signaling Pathway
Pathways		Pregnenolone biosynthesis
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Asthma ( 31959851) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Diisocyanate-induced asthma ( 25918132) Menarche (age at onset) ( 25231870) PR interval ( 32439900)
Interacting Genes		6 interacting genes: AGTRAP ARL6IP1 CCHCR1 GDAP1 MTIF3 SYP	41 interacting genes: AP1G1 ARFIP2 CAND2 CD160 DIABLO FARS2 GAB1 GDNF GRB2 HSFX1 HSFX2 JOSD2 LNPK MIEF1 MIEF2 MRM1 MRRF MTERF3 MYG1 NDRG4 PBX3 PITPNC1 PLIN3 PNKP PPIF PTCD1 PTPN9 RBFA SH3GLB1 SIAH1 SIAH2 SMG9 SNX1 SPG21 SSX5 STARD4 THAP4 TUFM VAMP2 WDFY2 WIPI2
Entrez ID		134429	6855
HPRD ID		06133	02435
Ensembl ID		ENSG00000164211	ENSG00000102003
Uniprot IDs		B0AZS2 Q96DR4	P08247
PDB IDs		6L1D 6L1M
Enriched GO Terms of Interacting Partners?
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