LIN54 and SF3A2

Data Source:
BioGRID (two hybrid)

		LIN54	SF3A2
Description		lin-54 DREAM MuvB core complex component	splicing factor 3a subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Regulatory Region Nucleic Acid Binding Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Metal Ion Binding	RNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Cycle Nucleosome Positioning Regulation Of Cell Cycle	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing Positive Regulation Of Neuron Projection Development U2-type Prespliceosome Assembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry	mRNA Splicing - Major Pathway
Drugs			Copper
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30224653 30578418) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)	Adult body size ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Myocardial infarction ( 24916648) Pulse pressure ( 26390057)
Interacting Genes		7 interacting genes: BANP NFYC RB1 SF3A2 SP3 ZNF143 ZNF76	20 interacting genes: APBB1 ASPH BAIAP2 BEND2 CDC42 GRB2 HTATSF1 LIN54 NCK2 OSTF1 PRPF40A RETN SF3A1 SH3RF1 SMURF2 TCERG1 TFG TRIP10 VEZF1 YY1
Entrez ID		132660	8175
HPRD ID		13218	02877
Ensembl ID		ENSG00000189308	ENSG00000104897
Uniprot IDs		Q6MZP7 Q7Z3G2	Q05DF2 Q15428
PDB IDs		5FD3	5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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