COL4A5 and FFAR2

Data Source:
BioGRID (two hybrid)

		COL4A5	FFAR2
Description		collagen type IV alpha 5 chain	free fatty acid receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix	Plasma Membrane Integral Component Of Plasma Membrane Cell Projection
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength	G Protein-coupled Receptor Activity Protein Binding Lipid Binding
	Biological Process	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway	Leukocyte Chemotaxis Involved In Inflammatory Response Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G Protein-coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-8 Production Glucose Homeostasis Fat Cell Differentiation Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs	G alpha (q) signalling events Free fatty acid receptors
Drugs
Diseases		Alport syndrome
GWAS			Hemoglobin ( 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		46 interacting genes: ABHD4 ANTXR2 ANXA7 APP ATP6V0B BSND CD53 CD79A CD93 CDKN1A CERS4 CLDN7 DAZAP2 DCN ELOVL4 ERGIC3 FAM209A FBLN2 FFAR2 FN1 GPX8 HABP2 KCNJ6 MATN2 MFF MMP9 MTIF3 NCR3LG1 NEMP1 NR1H2 OSM RELL2 RNF10 SAR1A SERPINE2 SLC10A4 SLC10A6 SLC16A2 SLC18A1 SLC35C2 SLC39A2 SMN1 THAP4 TK1 TMEM80 TSPO2	110 interacting genes: AGPAT4 AGTRAP ALOX5AP APOD ATP13A1 ATP6V0C BMP10 BNIP3 BTN2A2 C11orf24 C3orf52 C4orf3 CACNG1 CBLIF CCDC167 CD82 CDIPT CFHR5 CGRRF1 CLDN4 CLDND2 CLEC1A CMTM5 CMTM7 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB5R2 DERL1 EDDM3B EMP1 ERG28 FAM20B FAM3C FAXDC2 FCER1G FIS1 FXYD3 FXYD6 FZD7 GALNT15 GJB2 GNAO1 GNAQ GPR37L1 GUCA2A GYPA IFITM3 IGF1R KRT1 KTN1 LAPTM4A LAT LEPROTL1 LHFPL5 LPAR3 MALL MFSD5 MS4A13 NAT8 NIPAL4 NKG7 NRM NSG1 NUCB2 OR10AG1 PEX16 PLP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SACM1L SCGB1D1 SELENOK SLC30A2 SLC35B4 SLC35C2 SLC35E3 SLC38A1 SLC39A9 SLC41A1 SMAGP SMCO4 SMIM1 STRIT1 STX8 SYNDIG1 TEX264 TM4SF4 TMEM11 TMEM120B TMEM144 TMEM147 TMEM203 TMEM239 TMEM262 TMEM60 TMEM86A TMEM97 TNF TSPO2 UNC50 UPK1B YIF1A YIPF2 YIPF6
Entrez ID		1287	2867
HPRD ID		02363	04824
Ensembl ID		ENSG00000188153	ENSG00000126262
Uniprot IDs		A7MBN3 P29400 Q49AM6	C6KYL4 O15552
PDB IDs		5NAZ
Enriched GO Terms of Interacting Partners?
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