COL4A2 and BMP3

Data Source:
HPRD (in vitro)

		COL4A2	BMP3
Description		collagen type IV alpha 2 chain	bone morphogenetic protein 3
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Signaling Receptor Binding Cytokine Activity Growth Factor Activity BMP Receptor Binding
	Biological Process	Angiogenesis Transcription, DNA-templated Aging Response To Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Endodermal Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus	Skeletal System Development Osteoblast Differentiation Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cartilage Development SMAD Protein Signal Transduction
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Blood urea nitrogen levels ( 31152163) Coronary artery calcification ( 22144573) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878) Glomerular filtration rate ( 29403010) Intake of sweets ( 31005972) Ischemic stroke (small-vessel) ( 29531354) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Maximum retinal arteriolar tortuosity ( 31597446) Middle temporal gyrus volume ( 31530798) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage ( 31430377) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Retinal arteriolar tortuosity ( 31597446) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Corneal astigmatism ( 30306274) Height ( 18391951) Myopia ( 27182965) Optic disc size ( 31809533) Pubertal anthropometrics ( 23449627) Refractive astigmatism ( 30306274) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		24 interacting genes: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TENT5A TGFBI TK1 VHL	5 interacting genes: COL4A1 COL4A2 KDM1A PRMT6 TGFB1
Entrez ID		1284	651
HPRD ID		00355	00208
Ensembl ID		ENSG00000134871	ENSG00000152785
Uniprot IDs		A0A024RDW8 P08572	P12645
PDB IDs		1LI1 5NAX 5NB2 6MPX	2QCQ
Enriched GO Terms of Interacting Partners?
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