CNTF and CNTFR

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CNTF	CNTFR
Description		ciliary neurotrophic factor	ciliary neurotrophic factor receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Axon	Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Protein-containing Complex Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Astrocyte Activation Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Axon Regeneration Ciliary Neurotrophic Factor-mediated Signaling Pathway	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 23128233) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 29875488) Physiological traits ( 31902109)
Interacting Genes		13 interacting genes: AK8 APOE CNTFR CYSRT1 IL6R IL6ST KRT31 KRT40 LIFR NDUFAB1 RDM1 TEPSIN TRIP6	9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1
Entrez ID		1270	1271
HPRD ID		00347	00348
Ensembl ID		ENSG00000242689	ENSG00000122756
Uniprot IDs		P26441	P26992
PDB IDs		1CNT	1UC6
Enriched GO Terms of Interacting Partners?
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