ADH4 and RPL35

Data Source:
BioGRID (two hybrid)

		ADH4	RPL35
Description		alcohol dehydrogenase 4 (class II), pi polypeptide	ribosomal protein L35
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleolus Cytosol Membrane Cytosolic Large Ribosomal Subunit
	Molecular Function	NADPH:quinone Reductase Activity Alcohol Dehydrogenase (NAD+) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Alditol:NADP+ 1-oxidoreductase Activity Retinol Dehydrogenase Activity All-trans Retinal Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase [NAD(P)+] Activity Retinol Binding Ethanol Binding NAD Binding S-(hydroxymethyl)glutathione Dehydrogenase Activity	RNA Binding MRNA Binding Structural Constituent Of Ribosome
	Biological Process	Retinoid Metabolic Process Alcohol Metabolic Process Ethanol Oxidation Cellular Aldehyde Metabolic Process Fatty Acid Omega-oxidation Retinol Metabolic Process Alcohol Catabolic Process Formaldehyde Catabolic Process Quinone Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription
Pathways		RA biosynthesis pathway Ethanol oxidation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		NADH Cyclohexylformamide	Artenimol
Diseases
GWAS		Alcohol dependence ( 24166409 23456092) Alcohol use disorder ( 30940813) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Esophageal cancer (alcohol interaction) ( 22960999) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Regular attendance at a pub or social club ( 29970889) Serum metabolite levels ( 24625756) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: APP RPL35	9 interacting genes: ACTN2 ADH4 CDKN1A CREBBP DUX4 LAMC3 MAX SGSM3 TUBB2B
Entrez ID		127	11224
HPRD ID		00068	10200
Ensembl ID		ENSG00000198099	ENSG00000136942
Uniprot IDs		P08319 V9HVX7	P42766
PDB IDs		3COS	4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SXO 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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