ADH1B and IRAK3

Data Source:
BioGRID (two hybrid)

		ADH1B	IRAK3
Description		alcohol dehydrogenase 1B (class I), beta polypeptide	interleukin 1 receptor associated kinase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Alcohol Dehydrogenase Activity, Zinc-dependent Retinol Dehydrogenase Activity Zinc Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Retinoid Metabolic Process Ethanol Oxidation Retinol Metabolic Process Retinoic Acid Metabolic Process	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Ethanol oxidation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling
Drugs		NADH Fomepizole N-Benzylformamide 4-Iodopyrazole Nicotinamide adenine dinucleotide phosphate Cyclohexanol N-Heptylformamide Glycerin	Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption ( 23743675 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 31959922) Alcohol consumption (drinks per week) ( 28485404 30643258 31959922 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 24166409 23456092 28714907 31591379 31090166 22004471) Alcohol dependence (desire to cut drinking) ( 31090166) Alcohol dependence (tolerance) ( 31090166) Alcohol dependence symptom count ( 31090166) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Maximum habitual alcohol consumption ( 31151762) Metabolite levels ( 23823483) Oral cavity and pharyngeal cancer ( 21437268 27749845) Oral cavity cancer ( 27749845) Oropharynx cancer ( 27749845) Problematic alcohol use ( 32451486) Regular attendance at a pub or social club ( 29970889) Relative fat intake ( 32393786) Relative protein intake ( 32393786) Reticulocyte count ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Urinary sodium excretion ( 31409800)	Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		5 interacting genes: IRAK3 PDE4DIP PML RACK1 SERPINA3	17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		125	11213
HPRD ID		00065	05123
Ensembl ID		ENSG00000196616	ENSG00000090376
Uniprot IDs		D6RHZ6 P00325 V9HW50	Q9Y616
PDB IDs		1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD	5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?
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