SH2D1B and CD84

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SH2D1B	CD84
Description		SH2 domain containing 1B	CD84 molecule
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GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response	Adaptive Immune Response Autophagy Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Mast Cell Activation Negative Regulation Of Mast Cell Degranulation Innate Immune Response Leukocyte Migration Regulation Of Store-operated Calcium Entry
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Response to anti-TNF therapy in rheumatoid arthritis ( 23555300)
Interacting Genes		25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	2 interacting genes: SH2D1A SH2D1B
Entrez ID		117157	8832
HPRD ID		12248	05151
Ensembl ID		ENSG00000198574	ENSG00000066294
Uniprot IDs		O14796	Q9UIB8
PDB IDs		5KAZ	2PKD
Enriched GO Terms of Interacting Partners?
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