ERCC8 and CBR1

Data Source:
HPRD (two hybrid)

		ERCC8	CBR1
Description		ERCC excision repair 8, CSA ubiquitin ligase complex subunit	carbonyl reductase 1
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex	Cytosol Extracellular Exosome Extracellular Vesicle
	Molecular Function	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein-containing Complex Binding	Carbonyl Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin-E2 9-reductase Activity
	Biological Process	Single Strand Break Repair Protein Polyubiquitination Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Response To Organic Cyclic Compound DNA Duplex Unwinding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Repair Protein Autoubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining	Drug Metabolic Process Cyclooxygenase Pathway Epithelial Cell Differentiation Vitamin K Metabolic Process
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome Cockayne syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497)
Interacting Genes		11 interacting genes: CAMK2D CBR1 CSNK2B CUL4A DDB1 ERCC6 GTF2H2 RBX1 TOP1 UQCRQ XAB2	7 interacting genes: AGTR1 ERBB2 ERCC8 HTR2B PTPRF UBC VHL
Entrez ID		1161	873
HPRD ID		07523	00267
Ensembl ID		ENSG00000049167	ENSG00000159228
Uniprot IDs		A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216	A0A384NL53 P16152
PDB IDs		4A11 6FCV	1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D
Enriched GO Terms of Interacting Partners?
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