GABARAPL2 and NUDT15

Data Source:
BioGRID (two hybrid)

		GABARAPL2	NUDT15
Description		GABA type A receptor associated protein like 2	nudix hydrolase 15
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Vesicle	Cytosol
	Molecular Function	SNARE Binding Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Nucleoside-diphosphatase Activity NADH Pyrophosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity DTTP Diphosphatase Activity Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Macroautophagy Positive Regulation Of ATPase Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Nucleobase-containing Small Molecule Catabolic Process DNA Protection Exogenous Drug Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways		Macroautophagy TBC/RABGAPs	Phosphate bond hydrolysis by NUDT proteins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)	Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		89 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 BCL2L13 BNIP3L BSDC1 CALCOCO1 CALCOCO2 CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 HSP90AB1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP1LC3B MCPH1 MEFV MLX NBR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PTPRA RAP1A RAP2A RB1CC1 RCN2 RETREG1 RETREG3 RPS2 SCYL3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774	2 interacting genes: GABARAPL2 SRD5A3
Entrez ID		11345	55270
HPRD ID		16246	14848
Ensembl ID		ENSG00000034713	ENSG00000136159
Uniprot IDs		P60520	Q9NV35
PDB IDs		4CO7 6H8C	5BON 5LPG 6T5J
Enriched GO Terms of Interacting Partners?
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