GLCCI1 and VPS28

Data Source:
HPRD (in vivo, in vitro)

		GLCCI1	VPS28
Description		glucocorticoid induced 1	VPS28 subunit of ESCRT-I
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Late Endosome Membrane Host Cell Extracellular Exosome
	Molecular Function		Protein Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process		Endosomal Transport Macroautophagy Viral Life Cycle Negative Regulation Of Protein Ubiquitination Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Intracellular Transport Of Virus Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways			Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 24684796) Eosinophil counts ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 28552196 31562340) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 23836780) Macular thickness ( 30535121) Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event) ( 28753643) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Weight ( 28552196) White blood cell count ( 32888494)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988)
Interacting Genes		1 interacting genes: VPS28	45 interacting genes: ABI2 ASF1A BEX2 BLZF1 CARD9 CBX5 CCDC146 CDK18 CEP57L1 COX5B FABP3 GABARAP GEM GLCCI1 GOLGA2 INCA1 LMO3 MBIP NRDE2 NXF1 PDCD6IP PNMA5 PRKAA2 PRKAB2 RASSF5 SAXO1 SHC3 SKIL SMN1 SMN2 SUOX TCF12 TCF4 TRIM27 TRIM54 TSG101 TSNAX UBA52 UBC USHBP1 USP2 VPS37A VPS37B VPS37C VPS52
Entrez ID		113263	51160
HPRD ID		17043	11675
Ensembl ID		ENSG00000106415	ENSG00000160948
Uniprot IDs		Q86VQ1	A0A0S2Z5H5 Q548N1 Q9UK41
PDB IDs			6VME
Enriched GO Terms of Interacting Partners?
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