CHRM4 and CD59

Data Source:
BioGRID (two hybrid)

		CHRM4	CD59
Description		cholinergic receptor muscarinic 4	CD59 molecule (CD59 blood group)
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Anchored Component Of External Side Of Plasma Membrane Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	Complement Binding Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion G Protein-coupled Serotonin Receptor Signaling Pathway	Negative Regulation Of Activation Of Membrane Attack Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Neutrophil Degranulation COPII Vesicle Coating Regulation Of Complement-dependent Cytotoxicity
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events	COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs		Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)	Blood protein levels ( 30072576 29875488) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)
Interacting Genes		20 interacting genes: B2M CBFA2T3 CD59 CD81 EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 MFSD4A QSOX1 RAB3A RHBDD2 RTN4 SMIM7 SYN2 TM7SF2 TSPAN7 YIPF3	16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 EGFR FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC
Entrez ID		1132	966
HPRD ID		00330	00117
Ensembl ID		ENSG00000180720	ENSG00000085063
Uniprot IDs		P08173	P13987 Q6FHM9
PDB IDs		5DSG 6D9H 6KP6	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY
Enriched GO Terms of Interacting Partners?
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