MED8 and PEX14

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED8	PEX14
Description		mediator complex subunit 8	peroxisomal biogenesis factor 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mediator Complex Core Mediator Complex	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Identical Protein Binding Protein N-terminus Binding Beta-tubulin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Ubiquitination Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein-containing Complex Assembly
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 27182965 32296059) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		32 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49	14 interacting genes: CENPK COPS4 GET3 HDAC1 MARF1 MED8 MTNR1A NFE2 PEX19 PEX26 PEX5 PEX7 SMARCC2 ZHX1
Entrez ID		112950	5195
HPRD ID		06991	03477
Ensembl ID		ENSG00000159479	ENSG00000142655
Uniprot IDs		Q96G25	O75381
PDB IDs			2W84 2W85 4BXU
Enriched GO Terms of Interacting Partners?
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