DDX19B and NUP214

Data Source:
HPRD (in vitro)

		DDX19B	NUP214
Description		DEAD-box helicase 19B	nucleoporin 214
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Extracellular Exosome	Nuclear Pore Nucleoplasm Cytosol Host Cell Cytoplasmic Side Of Nuclear Pore
	Molecular Function	RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus	Mitotic Cell Cycle Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of MRNA Stability Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30578418)	Aspartate aminotransferase levels ( 31219225)
Interacting Genes		14 interacting genes: APP B3GALT4 DCK IKBKG MIF4GD NUP214 POT1 PRPSAP1 RACK1 RWDD2B SKP1 TERF1 UBC XPO7	20 interacting genes: APC CLEC4G DDX19B IPO5 NFX1 NUP107 NUP42 NUP62 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 XPO1 XPO5 XPOT ZFP36
Entrez ID		11269	8021
HPRD ID		05781	00258
Ensembl ID		ENSG00000157349	ENSG00000126883
Uniprot IDs		A0A024QZ90 A0A0U4B4U6 B4DL69 Q9UMR2	B7ZAV2 P35658
PDB IDs		3EWS 3FHC 3FHT 3FMO 3FMP 3G0H 6B4I 6B4J 6B4K	2OIT 3FHC 3FMO 3FMP 5DIS
Enriched GO Terms of Interacting Partners?
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