ZHX1 and PEX14

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZHX1	PEX14
Description		zinc fingers and homeoboxes 1	peroxisomal biogenesis factor 14
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Identical Protein Binding Protein N-terminus Binding Beta-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Ubiquitination Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein-containing Complex Assembly
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			Asthma ( 27182965 32296059) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		53 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	14 interacting genes: CENPK COPS4 GET3 HDAC1 MARF1 MED8 MTNR1A NFE2 PEX19 PEX26 PEX5 PEX7 SMARCC2 ZHX1
Entrez ID		11244	5195
HPRD ID		10379	03477
Ensembl ID		ENSG00000165156	ENSG00000142655
Uniprot IDs		A0A024R9F1 Q9UKY1	O75381
PDB IDs		2ECB 2GHF 2LY9 3NAR	2W84 2W85 4BXU
Enriched GO Terms of Interacting Partners?
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