AKAP13 and CTNNAL1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, in vitro, two hybrid)

		AKAP13	CTNNAL1
Description		A-kinase anchoring protein 13	catenin alpha like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cell Cortex Actin Cytoskeleton Membrane Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	CAMP-dependent Protein Kinase Activity MAP-kinase Scaffold Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity	Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Cell Growth Involved In Cardiac Muscle Cell Development Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process	Cell Adhesion Rho Protein Signal Transduction
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Birth weight ( 31043758) Central corneal thickness ( 32528159 31798171 29760442 20719862) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) High myopia ( 32428537) Idiopathic pulmonary fibrosis ( 31710517 29066090) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) Platelet count ( 32888494) Platelet distribution width ( 32888494) Psoriasis ( 25939698) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418)
Interacting Genes		21 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ	12 interacting genes: AKAP13 BRME1 CALU DMD NEK1 PCGF2 RNF135 SERTAD3 TRIM7 TSC22D4 USH1C ZBED1
Entrez ID		11214	8727
HPRD ID		05253	09210
Ensembl ID		ENSG00000170776	ENSG00000119326
Uniprot IDs		A8MYJ1 B0AZU4 Q12802	B3KMX6 Q9UBT7
PDB IDs		2DRN 2LG1 4D0N 4D0O 6BCA
Enriched GO Terms of Interacting Partners?
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