CHEK2 and PRKDC

Data Source:
BioGRID (enzymatic study, enzymatic study)

		CHEK2	PRKDC
Description		checkpoint kinase 2	protein kinase, DNA-activated, catalytic subunit
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body	Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Nonhomologous End Joining Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding U3 SnoRNA Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Double-strand Break Repair Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Peptidyl-serine Phosphorylation Cellular Response To Drug Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Negative Regulation Of Cell Cycle Arrest Cellular Response To Gamma Radiation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis	Maturation Of 5.8S RRNA Telomere Maintenance Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment Negative Regulation Of Immunoglobulin Production Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Response To Activity Telomere Capping Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Small-subunit Processome Assembly Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Rhythmic Process Spleen Development Thymus Development Positive Regulation Of Developmental Growth Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Platelet Formation Negative Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Response To Gamma Radiation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins
Drugs		XL844 Enzastaurin Fostamatinib	Caffeine SF1126
Diseases		Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS		Breast cancer ( 29059683 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 32888494 28957414) Vertical cup-disc ratio ( 20548946 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		80 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 POLR2L PPM1D PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B USP39 VHL	91 interacting genes: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C DUX4 E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R3 PRKCD PTEN RAD17 RASSF1 RBBP8 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TOP1 TP53 TREX1 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A
Entrez ID		11200	5591
HPRD ID		05084	02941
Ensembl ID		ENSG00000183765	ENSG00000253729
Uniprot IDs		O96017	P78527
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK	5LUQ 5W1R 5Y3R 6ZFP 6ZH2 6ZH4 6ZH6 6ZH8 6ZHA 6ZHE
Enriched GO Terms of Interacting Partners?
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