SUPT16H and GTF2E2

Data Source:
HPRD (two hybrid, in vitro)

		SUPT16H	GTF2E2
Description		SPT16 homolog, facilitates chromatin remodeling subunit	general transcription factor IIE subunit 2
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GO Annotations	Cellular Component	Nucleoplasm FACT Complex	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol Nuclear Speck
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	DNA Replication DNA Repair Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter DNA Replication-independent Nucleosome Organization Regulation Of Signal Transduction By P53 Class Mediator	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Cognitive performance ( 20125193) Mean corpuscular volume ( 32888494) Metabolite levels (X-11787) ( 23934736)
Interacting Genes		13 interacting genes: CCT6A GTF2E2 H2AC13 H2AX H3-3A MCM3 MCM4 NEK9 PARP1 SREK1 SRPK2 SSRP1 SUMO2	26 interacting genes: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 EXOC8 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KAT5 KLF5 MCC MDM2 MNAT1 NUP62 PICK1 SND1 SUPT16H TBP XPA
Entrez ID		11198	2961
HPRD ID		16088	01800
Ensembl ID		ENSG00000092201	ENSG00000197265
Uniprot IDs		Q9Y5B9	P29084
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL	1D8J 1D8K 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L
Enriched GO Terms of Interacting Partners?
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