ZNF277 and ZBTB7B

Data Source:
BioGRID (two hybrid)

		ZNF277	ZBTB7B
Description		zinc finger protein 277	zinc finger and BTB domain containing 7B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cellular Response To Hydrogen Peroxide Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II NK T Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ectoderm Development Lactation Positive Regulation Of Gene Expression Positive Regulation Of Histone Deacetylation Interleukin-17 Production Response To Insulin Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of NK T Cell Proliferation Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Adaptive Thermogenesis Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of SREBP Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Breast size ( 22747683) Early-onset Parkinson's disease ( 28256260) Refractive error ( 32231278)	Adult body size ( 32376654) Basal cell carcinoma ( 31174203) Bipolar disorder ( 31043756) Birth weight ( 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		9 interacting genes: CDCA8 COIL DDB1 GNGT1 MBD3 NUTM1 RPP14 ZBTB7B ZNF768	28 interacting genes: BCL6 BCL6B CCNL2 CRBN EP300 FAM90A1 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN OSTF1 P4HA3 PIN1 RELA RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 TRIP10 UBTFL1 ZBTB42 ZBTB5 ZNF277 ZSCAN5B
Entrez ID		11179	51043
HPRD ID		05680	09625
Ensembl ID		ENSG00000198839	ENSG00000160685
Uniprot IDs		Q9NRM2	O15156
PDB IDs
Enriched GO Terms of Interacting Partners?
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